Uncapped batsmen Prithvi Shaw and Hanuma Vihari have been included in India's squad for the final two Tests against England, the Board of Control for Cricket in India (BCCI) said on Wednesday.
Opening batsmen Murali Vijay has been dropped after his disappointing show in the first two Tests.
The 34-year-old was replaced by Shikhar Dhawan in the team for the third Test which the visitors won to narrow England's lead to 2-1 after three matches of the five-game series.
Wrist-spinner Kuldeep Yadav has also been sent home to play for India A team in two four-day matches against Australia A.
The 18-year-old Shaw earned his maiden Test call-up on the back of a string of strong performances for India A, including a knock of 188 against West Indies A last month.
Vihari has been one of the most consistent performers in domestic cricket, averaging 59.79 in 63 first-class matches.
Off-spinner Ravichandran Ashwin retained his spot in the squad despite struggling with a hip injury during the third Test.
The fourth Test begins on August 30 at the Rose Bowl in Southampton.
Full squad: Virat Kohli (captain), Shikhar Dhawan, KL Rahul, Prithvi Shaw, Cheteshwar Pujara, Ajinkya Rahane, Rishabh Pant, Dinesh Karthik, Hardik Pandya, Ravichandran Ashwin, Ravindra Jadeja, Jasprit Bumrah, Ishant Sharma, Mohammed Shami, Umesh Yadav, Shardul Thakur, Karun Nair and Hanuma Vihari.