With Australia looking on course for the final of the tri-series, it will be down to India and England to pick up victories in their next couple of games or so, and the best way to open up that path further to the summit clash is with a win in Brisbane.
India vs England is always an entertaining encounter, with the former going into the match as the favourites when it comes to the ODI format.
MS Dhoni's men came really close to stopping Australia in their first match of the tri-series in Melbourne on Sunday, but at the end of the day they paid for their poor finish with the bat in the final overs, where they lost out on at least 20 runs, owing largely to a tremendous bowling performance from Mitchell Starc.
England also have bowlers capable of stunting India's progress, even if they did not show that particular talent in their opening match of the series against Australia last Friday.
"Each side brings something different," said England batsman Joe Root. "India have got a few guys in great form with the bat and have got some very skilful bowlers.
"We have got our plans in place to try and combat that and make sure we do everything we can to make big scores and take 10 wickets."
While India's strength clearly lies in their batting, England are not quite sure of their own prowess with the willow yet, and Root, no doubt, will be one of the crucial players for his team in this tri-series and the World cup after that.
England made the most disastrous of starts in their first game against the Aussies, losing two wickets in the very first over, which pretty much ended the match as a contest.
Runs at the top of the order, and plenty of them, will be vital for England, and with India's bowlers far from assured themselves this game could be perfect for the top few batsmen to gain some confidence.
"If we are going to make big scores we need the top four to get the majority of the runs, we know that," said Root, who failed with the bat in Sydney. We have proved that in the lead-up to this series, in our warm-up games and out in Sri Lanka as well.
"This is the side that is going to be taken to the World Cup, the squad that is going to be taken into the World Cup, and we know where we are at as a squad.
"We know we have got the right men in the dressing room to win games of cricket. Hopefully we can prove that throughout this tri-Series.
"We are here to win games of cricket. There is a World Cup round the corner so this is a massive series for us, we need to bounce back from last week."
India lost too many wickets early in the innings against Australia, then completely lost the plot in the final few overs, after some brilliant recovery work from Rohit Sharma and Suresh Raina, which in the end hurt them dear. The bowling, while far from consistent, at least showed they are capable of defending a total, as long as it is a decent one, and it will be up to the batsmen to lead by example, especially if they end up batting first again.
England could bring back James Anderson, if the swing bowler recovers from injury, while Dhoni is unlikely to risk either of Ravindra Jadeja or Ishant Sharma again, with Stuart Binny in with a slight chance of making the playing XI if the pitch at the Gabba looks like it might help the faster bowlers.
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India vs England Tri-series match three is set for a 2.20 pm AEDT (8.50 am IST, 3.20 am GMT) start with live coverage in India on Star Sports 1, Star Sports 3 (Hindi) and Star Sports HD1. Audience in India can watch the match online via free live streaming on Starsports.com or via the Starsports Live Pro option.
Viewers in the UK can catch England vs India live on Sky Sports 2 or by live streaming on Sky Go or Watch Sky Sports. Watch Match 3 of the Carlton Mid Tri-Series live in Australia on Channel 9, while the option to live stream is on Cricket Australia Live or the Cricket Australia Live App.
India vs England can be watched live by audience in the USA on Willow TV while the match can also be live streamed on Willow TV Online. Viewers in the Middle East and North Africa can catch the big ODI match live on OSN with the live stream option on OSN Play.
Confirmed lineups: India: Ajinkya Rahane, Shikhar Dhawan, Virat Kohli, Ambati Rayudu, Suresh Raina, MS Dhoni, Stuart Binny, Akshar Patel, Bhuvneshwar Kumar, Mohammed Shami, Umesh Yadav.
England: Ian Bell, Moeen Ali, James Taylor, Joe Root, Eoin Morgan, Jos Buttler, Ravi Bopara, Chris Woakes, Stuart Broad, James Anderson, Steven Finn.