World No 1 Novak Djokovic could be in line to face the eighth seeded Rafael Nadal in the quarter finals of the US Open 2015. The Serbian begins his campaign at the Flushing Meadows this year against Brazil's Joao Souza in the opening round.
"King of Clay" Nadal can also have it relatively easy in the first round as he goes head-to-head with Croatian teenager Borna Coric in the competition.
In the women's category, top seed Serena Williams goes head-to-head with Vitalia Diatchenko of Russia in the opening round, and could well meet her younger compatriot Sloane Stephens in the third round, Agnieszka Radwanska in the round of 16, and also be in line of a mega clash with Maria Sharapova in the semis.
Other potential quarter final games in the US Open this year includes a clash between 2015 French Open Champion Stan Wawrinka and World No 3 Andy Murray, who comes into the tournament after winning the Montreal Masters this year.
One of them can also be in line to face World No 2 Roger Federer in the semis of the competition this year. The Swiss tennis veteran starts his campaign in the final grand slam of the calendar year against the 31-year-old Florian Mayer.
Federer is drawn alongside Tomas Berdych, John Isner, Richard Gasquet, and Australian Lleyton Hewitt.
Britain's top seed Murray faces the controversial Australian tennis player Nick Kyrgios in the opening encounter of the tournament. Kyrgios has been all over the news this summer for all the wrong reasons as he hurled an indecent barb on Wawrinka during a Rogers Cup match earlier this month.
Men's defending champion Marin Cilic will have it relatively easy in the opening round this year as he faces a qualifier.
The lanky Croatian is drawn in the same quarter as that of last year's finalist Kei Nishkori, Jo-Wilfried Tsonga, David Ferrer, Gael Monfils and Grigor Dimitrov in the top half.
Russia's Sharapova could go head-to-head with Ana Ivanovic in the quarters, before a potential semi-final clash with the defending women's singles champion.
Last year's finalist Caroline Wozniacki is drawn in the bottom half, and could be in line to face former US Open champion Samantha Stosur in the round of 16, and two-time Wimbledon winner Petro Kvitova in the quarters.
The 33-year-old Serena, who is tagged as the favourite in the women's category this year, is looking to bag the calendar-year grand slam. Apart from Sharapova, she can also meet her sister Venus Williams in the quarters, and a potential clash with the second seeded Simona Halep in the final is also possible.
"I love winning here, I love playing here. That's all I want to do," Serena said. "I don't feel the pressure right now. I'm really just here to perform and do the best I can."
"I always dreamt of winning the US Open. My dream was always to win here in New York."