Asian stocks wavered on Thursday as investors grappled with the apparently diminishing ability of major central banks to stimulate growth, while a tumble in crude oil prices added to the risk-averse mood.
While expectations over a Federal Reserve rate hike at next week's meeting have faded, investors are bracing for a tightening before year-end.
Perceived limits to the extensive monetary easings led by major central banks such as the European Central Bank and the Bank of Japan have also soured broader risk sentiment, driving global debt yields higher.
MSCI's broadest index of Asia-Pacific shares outside Japan edged down 0.1 percent.
Australian stocks shed 0.2 percent and Shanghai lost 0.7 percent. South Korea's Kospi rose 0.4 percent and Japan's Nikkei slid more than one percent to a three-week low.
"Worries that the BOJ is struggling to come up with effective policy are making investors risk averse," said Yoshinori Shigemi, global market strategist at JPMorgan Asset Management in Tokyo.
The Fed and the BOJ both hold two-day policy meetings that end next Wednesday, with the BOJ due to comprehensively review its policies.
The BOJ has resorted to a range of unconventional policy steps such as negative interest rates, which some now see becoming the centerpiece of future monetary easing.
The soggy Asian session followed an uninspiring performance overnight on Wall Street where the Dow lost 0.2 percent and the S&P 500 shed 0.1 percent, with uncertainty over future interest rate hikes and lower energy shares weighing.
The Bank of England will be a focus on Thursday. The central bank is seen standing pat after easing policy last month, amid signs it overestimated the initial shock to Britain's economy from June's Brexit vote.
"Having just increased stimulus in August, the BoE won't be eager to add bond purchases or cut interest rates again," wrote Kathy Lien, managing director of FX Strategy at BK Asset Management.
"Recent data shows how their efforts have paid off so while the BoE will leave the door open to additional stimulus, they should note the improvements in the economy and signal to the market that they are in wait-and-see mode."
Elsewhere, the dollar slipped 0.3 percent to 102.150 yen. It had briefly risen above 103.00 the previous day on speculation the BOJ would increase stimulus next week.
The euro was steady at $1.1247.
Brent crude limped up 0.5 percent to $46.08 a barrel LCOc1 after dropping 2.6 percent on Wednesday when data showing large weekly builds in U.S. petroleum products offset a surprise draw in crude stockpiles.
The 10-year U.S. Treasury note yield US10YT=RR stood at 1.702 percent after sliding overnight to as low as 1.682 percent.
The fall in the 10-year yield slowed as bond market weakness, which had sent it to a three-month high of 1.752 percent earlier this week, ebbed slightly.
Long-dated bonds have underperformed for much of the past month along with a steepening yield curve in Japanese government bonds. The BOJ is studying options to steepen the yield curve to help prompt new lending by banks that have been hurt by low long-term rates.