Germany will want to firm their grip on top spot in Group D, while Scotland will try to cling on to their fading hopes of qualifying for Euro 2016 when the two sides meet in Glasgow on Monday.
Scotland are still reeling from the 1-0 reverse at Georgia on Friday, which put a major dent in their hopes of qualifying in the top two from Group D. The top two teams will automatically move into the finals of Euro 2016, while the third-placed team will, most probably, have to go through via a playoff.
That third place is currently held by Republic of Ireland, who are a point ahead of Scotland, and host Georgia on Monday.
While three points against the world champions, the current group toppers, will put them right back in contention for an automatic berth, Scotland manager Gordon Strachan admitted he will be happy to take a point off Germany.
"I am looking for a point," Strachan said. "I want three. But I have to pick a team in mind where I want a point but I want three as well. I don't think anybody knows how to play for a draw.
"We are not saying it's over and done with if we don't get it, but I am more than confident we will get something from the game. We've got our frustration out in the last couple of days in training and we've been watching bits and bobs of video.
"We've got to try and get our minds set on the fact that we are playing the world champions here at Hampden, and that anything can happen. We've done it here before and we know we can do it again."
Germany climbed back to pole position in Group D with a 3-1 win over Poland on Friday, and with the attackers firing in the goals again, the Scotland defence will have to be at their best to keep the world champions from scoring.
However, Germany manager Joachim Low believes Scotland will be tricky opposition, as they will want to bounce back from that forgettable defeat to Gerogia, a match in which the Scots did not have a single shot on target.
"I don't think Scotland losing to Georgia will be of any advantage to us, not in the least," Low said. "That won't do their fighting spirit or passion any damage at all. I know that the squad and the coach will be disappointed about that result, but, if anything, it will make them even more dangerous.
"I think they will quickly put their Georgia defeat aside and they will want to reboot themselves and their team. Whenever they are up against elite opponents, Germany, England or other big-time opposition, they give everything they've got from the first minute to the last."
Where to Watch Live
Germany vs Scotland is scheduled for an 8.45 pm CET (12.15 am IST, 7.45 pm BST, 2.45 pm ET) start with live coverage in India on Sony Six. The Euro 2016 qualifier can also be watched via live streaming online on Livsports.
Sky Sports 1 will show the vital European qualifier live in the UK, including Scotland, while the match can also be live streamed on Sky Go. Australia audience can catch Scotland vs Germany live on ESPN, while the match can be live streamed on ESPN Player.