Republican presidential candidate Jeb Bush lashed out at rival Marco Rubio in a spirited debate on Wednesday, joining a Florida newspaper in suggesting Rubio should resign his Senate seat given all of his missed votes.

With time running short until the first nominating contest in three months, the Republicans were quick to leap to the attack at a debate that featured frequent personal criticism and many candidates talking over the moderators in their haste to make points.

Rubio, a U.S. senator from Florida, defended his record of missing about one-third of his Senate votes this year while campaigning for the White House and said a Florida newspaper's call for him to resign was evidence of "the bias that exists in the American media today."

Bush, former Florida governor and once considered a mentor to Rubio, was not buying the explanation.

"Just resign and let someone else take the job," Bush said. "This is a six-year term, and you should be showing up to work. Was this a French work week?"

U.S. Senator Ted Cruz of Texas ignored a question on the debt limit to criticize the CNBC debate moderators for the questions they had posed to candidates.

"The questions that have been asked so far in this debate illustrate why the American people don't trust the media," he said. "This is not a cage match. How about talking about the substantive issues?"

The Republicans seeking their party's nomination for the November 2016 election also clashed over their tax plans, with front-runner Ben Carson defending his Bible-inspired proposals and former business executive Carly Fiorina vowing to reduce the complicated tax code to three pages.

Carson, a retired neurosurgeon, said his plan, which is based on religious tithing principles, would get rid of deductions and loopholes and constitute a flat rate of about 15 percent that would be sufficient to fund a sharply reduced government.

"Remember, we have 645 federal agencies and sub-agencies. Anybody who tells me that we need every penny in every one of those is in a fantasy world," Carson said.

Fiorina, a former executive at Hewlett-Packard, said she would reduce the tax code to three pages to level the playing field for all Americans.

"Three pages is about the maximum a single business owner, or a farmer, or just a couple can understand without hiring somebody," she said.

Ohio Governor John Kasich was quick to go on the attack against billionaire developer Donald Trump, calling his tax plan "a fantasy."

"We are on the verge of picking, perhaps, someone who cannot do this job," Kasich said. "You gotta pick somebody who has experience."

The debate comes at a crucial time in the race for the 2016 Republican presidential nomination, as Carson has moved ahead of Trump in some national and local polls. The latest Reuters/Ipsos poll shows the two front-runners in a dead heat.

Lagging contenders such as Bush and Rubio are running out of time to turn the tide in a campaign dominated by provocative rhetoric that has played to the strengths of Trump, a bombastic reality television star and developer, and Carson, a soft-spoken neurosurgeon.

Before the main event, four low-polling candidates held a separate debate. U.S. Senator Lindsey Graham of South Carolina turned in a strong performance against Louisiana Governor Bobby Jindal, former New York Governor George Pataki and former U.S. Senator Rick Santorum of Pennsylvania.

All of the low-polling candidates took shots at Democratic front-runner Hillary Clinton and her rival U.S. Senator Bernie Sanders, a democratic socialist from Vermont, but Graham had the sharpest aim.

"Good God, look who we're running against," Graham said. "The number-one candidate on the other side thought she was flat broke after her and her husband were in the White House for eight years. The number-two guy went to the Soviet Union on his honeymoon, and I don't think he ever came back."