When season two of "Reign" returns this October, the period drama might take a dramatic turn, and death is a sure sign, thanks to the plague that arrived in the final moments of season one.

The plague changes the dynamics of the court and the season two premiere will feature a casualty because of the plague. "This season is about what rises from the ashes of the plague," Laurie McCarthy, executive producer of "Reign," said at Comic-Con, according to BuddyTV.

It is yet to be revealed who is on the chopping block, but rumors swirling around have pitched the names of the series' lead character Mary, played by Adelaide Kane, as well as Francis.

In the first season of the period drama, Mary initially decides against marrying Francis because of Nostradamus's prophecy that Francis will die soon after his wedding with Mary. But later, Mary and Francis get married after Nostradamus sees another vision, which indicates that Francis will not die.

However, things go awry when Nostradamus again gets a premonition about Francis' death, and since then fans have been expecting the character essayed by Toby Regbo to die.

Similarly, Kane, too, sparked death rumors when she hinted at Comic-Con that although she wants her character to have a baby, it does not seem like a possibility.

"We'll see how long the show goes for because I would love to get around to her second marriage and her bearing a child. I'm very excited to have a baby. That will be very exciting," Kane said, according to Fanbolt.

"I don't think we're going to get around to that, I don't know if we're going to get around to her being beheaded. We might fudge that if we know that we're going to wrap up at the end of the season, we might say cut to whatever or we might just leave it. I don't know if we're going to get to her death…We could get to that point over the next 3 or 4 seasons in which case I'll be 27, 28 and still too young. She died in her 40′s…" she added.

Season two of "Reign" is expected to premiere on Thursday, Oct. 2 at 9 p.m. ET on The CW.