Manchester United will want to cut the gap on the top four further, Liverpool will target a return to winning ways, with Manchester City the same, while Chelsea will look to make it a perfect ten as Wednesday's Premier League matches come to the fore.
With the festive season quickly descending upon us, none of the teams in the top half or the bottom will want to find themselves already fighting a losing battle. Winning games and building momentum going into the festive run-in is crucial.
Here is a look at the matches, schedule, time, date, venue and TV guide of all the eight matches in the Premier League on Wednesday.
Crystal Palace vs Manchester United (8pm GMT, 3pm ET, 1.30am IST) at Selhurst Park: Alan Pardew remains under pressure, after another crazy, high-scoring match. Palace are only three points off the drop zone, and Pardew cannot afford another energy-sapping defeat. Manchester United, though, are coming off a morale-boosting victory over Tottenham, and Jose Mourinho will look to take that confidence into this game against a you-know-their-defence-is-suspect Crystal Palace.
Stoke City vs Southampton (8pm GMT, 3pm ET, 1.30am IST) at bet365 Stadium: The Saints might be injury hit, but they still found a way to take the three points from their last match, when Sofiane Boufal struck a gem of a winner. Stoke are coming off a loss to Arsenal in a match which they did not play too badly. Mark Hughes will know if his team take their chances at home, three points could come their way against Southampton.
Tottenham vs Hull City (8pm GMT, 3pm ET, 1.30am IST) at White Hart Lane: How the Tottenham momentum has stalled. Spurs are out of the Champions League and ten points off leaders Chelsea after their second defeat of the season came at the hands of Man Utd. The press-perfect performance against City seems like ages ago, and Spurs need to find that groove again. A match against Hull City shouldn't present too many problems, so expect Harry Kane and co. to find a few goals.
West Bromwich Albion vs Swansea City (8pm GMT, 3pm ET, 1.30am IST) at the Hawthorns: West Brom nearly ended Chelsea's winning run, before some individual brilliance from Diego Costa meant they left Stamford Bridge empty-handed. Tony Pulis' side, however, are playing some good football (no, really), but they will need to be at their best to trump a relegation-threatened Swansea City, coming off an impressive 3-0 win over Sunderland.
Manchester City vs Watford (8pm GMT, 3pm ET, 1.30am IST) at the Etihad Stadium: Pep Guardiola is certainly learning how difficult the Premier League is and how intense every single match is. Leicester City were brilliant on the counter-attack and picked them off a little too easily on Saturday. Watford will try and take advantage of the iffy defence as well, but expect City to bounce back.
Sunderland vs Chelsea (7.45pm GMT, 2.45pm ET, 1.15am IST) at Stadium of Light: Impregnable defence and an unstoppable offence – Chelsea just have it going right now and considering this match will be against the bottom club in the Premier League, irrespective of decent recent form, there looks like being only one result.
West Ham vs Burnley (7.45pm GMT, 2.45pm ET, 1.15am IST) at London Stadium: The Hammers will still be ruing the Liverpool draw, knowing there was three points there for the taking, considering the Reds only equalised off a mistake by the goalkeeper (Liverpool fans will say the same the other way around as well, though). Burnley were impressive in a 3-2 win over Bournemouth at the weekend, so the momentum is with them coming into this match. Slaven Bilic, however, needs a win to ease the pressure, and it might just come with this game.
Middlesbrough vs Liverpool (7.45pm GMT, 2.45pm ET, 1.15am IST) at the Riverside Stadium: A dramatic loss to Bournemouth and a not-that-impressive draw with West Ham have killed Liverpool's mojo. Jurgen Klopp will know Boro will provide a stern test on Wednesday and Liverpool will need to be at their attacking best to find a way through, while sorting out that sometimes-calamitous back four of theirs at the other end.