Tottenham will target group stage perfection when they host Anzhi Makhachkala in the Europa League at White Hart Lane on Thursday night.
Spurs, already qualified for the last 32 as Group K winners, have won all five of their games in the Europa League so far this season, and Villas-Boas will be keen to make it six out of six before the knockout stages arrive.
Anzhi have also qualified from Group K as runners-up, making this game pretty much a dead rubber, but Spurs midfielder Sandro believes a victory is necessary to build confidence ahead of a tough round of English Premier League festive fixtures.
"We have to win every game," the Brazilian told Tottenham's official website. "It's one more game but we will do our best. We have to win every game to make ourselves even stronger for the next one and we are in the right position to do this."
Sandro also believes Tottenham are capable of going all the way in the competition, despite the likes of Juventus, Napoli and Porto set to make their mark in the Europa League after failing to advance to the knockout rounds of the Champions League.
"To win this competition would be very good," he added. "We have a great team so we just need to play to win as many games as we can. It's a great opportunity for us to win this competition."
Tottenham were 2-0 winners in the reverse fixture in Russia in October, thanks to goals from Jermain Defoe and Nacer Chadli, and the Premier League side will be confident of another positive result on Thursday.
Villas-Boas is again expected to rest a few players, with a crunch Premier League match against Liverpool on the horizon. "It has been our pattern in the Europa League to make seven, eight changes or more, it has worked well for us, we have the quality in our squad and have maximum points so far," Villas-Boas said. "We will continue to do that."
The manager is expected to give Danny Rose and Christian Eriksen, on their return from injury, a run-out against Anzhi. "We will look to try and give Danny Rose a couple of minutes in this game and Christian Eriksen is also selected, so there is the possibility that he could play some minutes as well," Villas-Boas added.
Jan Vertonghen (ankle), Harry Kane (back) and Younes Kaboul (quad) remain ruled out, with Vlad Chiriches also set to miss the Anzhi encounter, although the defender might make it for the Liverpool game.
"There is a good possibility that Vlad might be available for the game against Liverpool, but not tomorrow [Thursday]," Villas-Boas said.
Where to Watch Live
The game is scheduled for a 1.35 am IST start with live coverage on Ten Action. You can also catch the action live online by clicking HERE. Viewers in the U.S. can watch the match via live streaming by clicking HERE. To live stream the game in the U.K., click HERE. Viewers in North Africa and the Middle East can click HERE.