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Arsenal and Borussia Dortmund, as they sweat it out at the Westfalenstadion in the Champions League, will also be hoping for some help from Marseille, with the French side facing off against Napoli.
Dortmund, Arsenal and Napoli are all on six points from three matches each, with Marseille pointless, leaving the fight for the top two places in Group F as close and tight as they come between the top three sides.
If Marseille beat Napoli on Wednesday, then that result allows either Arsenal or Dortmund to establish themselves at the top of the table. Of course it could go the other way as well with Napoli winning, and Arsenal and Dortmund only managing to draw, leaving the two favourites in the group looking up at Rafa Benitez's side.
Benitez insisted he is not concerning himself too much with the permutations and combinations in the group and just wants his side to play some good football and get the desired result - three points against Marseille.
"We need to focus on this game against Marseille without thinking of the permutations," Benitez said. "Of course I would have preferred an easier group in the Champions League, but we cannot change teams. There are no poor sides in the Champions League.
"Finding the right balance takes time, and we still have to improve the cohesion of the group. I will not ask my players to focus on goal difference because the important thing is to play to win. Goal difference does not matter that much because it is our duty to win."
Marseille manager Elie Baup, whose side went down to Napoli 2-1 in the reverse tie, realises there is little chance of his side qualifying for the knockout stages, and therefore wants Marseille to play for pride and at least come away with a point against Napoli.
"We're playing for pride, to put our club in a favourable light," he said. "Today we have zero points in the group, but we hope to get at least a point tomorrow [Wednesday]. This match is important. Some people say it is not worth fighting in this competition because we are on zero points, but participating in the Champions League is always something special and unique."
Team News: Napoli will be without Miguel Britos (dislocated collarbone), Camilo Zuniga (knee) and Giandomenico Mesto, who suffered knee ligament damage at the weekend.
Marseille will have to do without the services of defenders Lucas Mendes and Rod Fanni against the Italians.
Key men: Napoli: Marek Hamsik has not quite set the Champions League on fire this season, and this match against Marseille might just be the tonic needed for the playmaker to come to the fore.
Marseille: Andre-Pierre Gignac will be the man that Baup looks towards for goals, something that Marseille will undoubtedly need to come away with a positive result, considering Napoli's attacking prowess.
Where to watch
The match is scheduled for a 1.15 am IST start on Thursday morning with no live coverage.
Expected lineups: Napoli: Reina; Armero, Albiol, Fernandez, Uvini; Inler, Behrami; Hamsik, Callejon, Insigne; Higuain.
Marseille: Mandanda; Morel, Diawara, N'Koulou, Abdallah; Cheyrou, Romao, Valbuena, J. Ayew, A. Ayew; Gignac.
Prediction: 2-0 to Napoli