Chelsea will look to maintain their unbeaten start to the season when they host Tottenham in the London derby on Wednesday, while Spurs will look to finally lift their Stamford Bridge curse.
The Blues have not lost in their first 13 league matches (20 games in all competitions) this season. Jose Mourinho's men are six points clear of second-placed Manchester City already and have also qualified to the Round of 16 of the Champions League as group toppers.
Chelsea, however, were held 0-0 by 14th-placed Sunderland at the weekend, and the league leaders will now be looking to get back to winning ways against London rivals Spurs.
Meanwhile, Mourinho insists his team is not trying to emulate Arsenal's Invincibles and will take risks in order to win matches, even if it means suffering occasional defeats.
"We are not playing for that. If against Spurs we have a 0-0 with 20 minutes to go, we are not going to play for the 0-0 to be undefeated after 21 matches. No way. If you play for that, if that is one objective, maybe you draw so many matches, you don't take risks to try and win matches. You are happy just to be undefeated," the Portuguese tactician pointed out.
"If you get 10 draws, you get 10 points. If you win five and lose five, you make 15 points. We are going to play matches to win. And, sometimes, we will lose. I'd prefer 15 points and lost matches than 10 points and being undefeated."
Spurs, on the other hand, have bounced back from their early season woes and have now posted three wins within the last week, beating Hull City and Everton, either side of a victory over Partizan Belgrade.
Mauricio Pochettino's side are now ninth in the league table, four points behind fourth-placed Manchester United - who have played an extra match, and have booked their place in the knockout stages of the Europa League as well.
However, the north London outfit are yet to win a league match at Stamford Bridge since 1990, and were comprehensively beaten 4-0 in the same fixture last season. But Pochettino insists he is not bothered by that stat.
"This record will not affect us; I'm not reading anything into it. For us it's important to go with the same mentality that we showed against Everton and forget the past - we don't let the past affect our present," the Argentine stressed.
Chelsea: Didier Drogba and Loic Remy are in contention to start up front in place of Diego Costa, who serves a one-match suspension after seeing his fifth yellow card of the season at Sunderland.
Spurs: Emmanuel Adebayor, Andros Townsend, Etienne Capoue, Vlad Chiriches, Danny Rose and Kyle Walker are all doubtful for tonight with their respective injury and fitness concerns.
Chelsea: Courtois; Ivanovic, Cahill, Terry, Azpilicueta; Matic, Fabregas; Willian, Oscar, Hazard; Drogba
Spurs: Lloris; Naughton, Fazio, Vertonghen, Davies; Bentaleb, Mason; Lennon, Kane, Eriksen; Soldado
Where to Watch Live
Chelsea vs Spurs is scheduled for a 1.15 am IST (7.45 pm GMT, 2.45 pm ET) start, with live coverage on Star Sports 2. The game can also be watched via live streaming online in India on Star Sports online.
Viewers in the UK can listen to the match live on BBC Radio 5 Live or on the website. Catch the action in the US on TV on NBC Sports, while the game can also be live streamed online NBC Sports Live Extra.
Viewers in the Middle East and North Africa can watch the match on beIN Sports Arabia 1HD and beIN Sports Arabia 11HD, or via live streaming online courtesy beIN Sports Connect. South Africa and Sub Saharan Africa viewers can watch the match on SuperSport 3 Africa or SuperSport online.