Chelsea travel to the St Mary's to take on Southampton as they look to cement their place at the top of the Premier League.
As the Blues are now out of the Champions League as well as the FA Cup, they will be focusing all their energies on winning their first Premier League title in five years.
The North London side are in a very good position in the Premier League as they are currently five points ahead of Manchester City despite playing two less games than Manuel Pellegrini's men.
This means that Chelsea will be opening an 11-point cushion between themselves and the defending English champions if they manage to win both their games in hand.
And Blues boss Jose Mourinho admits that his side are in a very good position in the Premier League at this stage of the season.
"It's more difficult to start the season on the same points as everybody than to play now with an advantage," the Portuguese told Chelsea's official website.
"We started the season with the same amount of points as Man City, now we have five more. We started the season on the same number of points as Arsenal, now we have nine more, so it's easier."
"All we can do now for ourselves and our club is win the Premier League. It's only one competition for us now. Our situation is good, everyone would love to be in our position."
Although Chelsea have been very solid at the back for the most of this season, Mourinho insists that there is still room for improvement especially in set piece situations.
"In the last four games we had two clean sheets and conceded three goals," he explained. "The three goals we conceded were headers from corners – one against Burnley and two against Paris Saint-Germain - we know that and obviously we will work on it.'
Meanwhile, Southampton will also be hoping to get a positive result against the Blues, despite them being the underdogs in this fixture.
The Saints have played brilliantly under Ronaldo Koeman this season, rising to as high as the third position in January.
However, the pressure seems to have gotten the better of them as they have been struggling of late, managing to record two wins in their last six Premier League fixtures.
This recent drop in form has resulted in them dropping to the seventh place in the Premier League, four points below a Champions League position.
They still have a chance of making a decent finish in the Premier League this season, but in order to do so they need to start winning matches.
However, the Saints will certainly not have an easy time against Chelsea, and Ronaldo Koeman admits the Blues will be hungry for a win following their exit from the Champions League.
"They will do everything to beat us," the Dutchman told the Mirror. "They need a win after the disappointing result but the players and the manager have the experience to cope with that."
Although Chelsea are now expected to win the Premier League, the 51-year-old insists that the remaining games are not going to be easy for Mourinho's men.
"They are still the leaders but it is not easy to win games in the Premier League. For Chelsea the final part of the season is not going to be easy. They have many difficult games coming up but they have the experience to deal with it."
Chelsea: Courtois; Ivanovic, Cahill, Terry, Filipe Luis; Ramires, Matic; Cuadrado, Oscar, Hazard; Diego Costa
Southampton: Forster; Clyne, Fonte, Alderweireld, Bertrand; Wanyama, Schneiderlin, Djuricic, Elia, Mane; Pelle
Where to Watch Live
The EPL match is scheduled for 1:30pm GMT (7pm IST, 9:30am ET), starting with live coverage in India on Star Sports 4 and Star Sports 4 HD in India. The game can also be watched via live streaming online in India on StarSports.com.
Catch the action live in the UK live on Sky Sports 1 and Sky Sports 1 HD, while viewers can also watch the watch online via live streaming on Sky GO. Catch the game live in the US on NBSCN, while the action can also be live streamed online on NBC Sports Extra.
Audience in the Middle East and North Africa can watch the game via live streaming online on Bein Sports Connect, while South Africa and Sub Saharan Africa viewers can do the same on SuperSport online. Australia viewers can watch the game on Fox Sports and live stream it on Fox Sports On Demand.