Lionel Messi and Neymar showed why they are two of the best players in the world in the 4-0 spanking of Manchester City a couple of weeks ago, and when the Champions League returns with Barcelona set to play Guardiola's team again, this time at the Etihad, expect the two superstars to make an impact one more time.
Messi took advantage of a Manchester City slip to score his first goal after showing some exquisite balance, before the Argentine showed his ruthless streak, taking advantage of the extra man to put the Premier League club to the sword and with it completing his hat-trick.
Neymar would also add his name to the scoresheet late in the game, and Guardiola has no doubts over the two players that City will need to stop the most if they are to stand a chance of getting anything out of this Group C Champions League game.
"The two wide players from Barcelona are almost unplayable," Guardiola said of the Argentinian and Brazilian.
It is not just Neymar and Messi, though. There is also a certain Luis Suarez, and you waste too many resources worrying about just the wide players, Suarez will take full advantage of the space and City will find they are a couple of goals in a hurry.
While there are question marks over Barcelona's midfield and defence, owing to injuries, City will know that "MSN" front three can decimate any team in the world at any time – all they need is one chance.
Guardiola will want to have greater control of the game, while also hoping all 11 of his players stay on the pitch. The last thing the Spaniard will want is to have to play a man down again against arguably the best club team in the world.
Messi, Neymar and Suarez are lethal enough against 11 men, you give them an extra advantage, they will rip you to shreds, as they showed in the game at the Camp Nou.