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Viktoria Plzen and CSKA Moscow, their fates already sealed in the Champions League, will fight it out for the consolation prize - a place in the Europa League - when the two sides meet in their final group game on Tuesday.
Bayern Munich and Manchester City have already booked the two available last 16 places from Group D, leaving the other two to scrap it out for third.
CSKA, who have three points from five matches, are in pole position, with a draw enough to ensure third spot. Viktoria Plzen, who have yet to pick up a single point in the group, need to beat CSKA at home to stand any chance of continuing their European adventures this season.
"The situation means this is pretty much a play-off tie," said Pavel Vrba, who manages his last game at Plzen before taking over the reins as Czech Republic coach. "We lost the away game 3-2, not a bad result and one that gives us a decent chance of progress. With our fans behind us and the quality in our squad we will manage to overturn the deficit and finish third.
"I expect that CSKA will come out with the home result in mind and focus on watchful defence in a tactical lineup like they used against Bayern and Manchester City, relying on fast counterattacks. We have to avoid conceding the opening goal and pay attention to the exceptionally fast-footed CSKA players. This will be key to our success.
"We could become the first Czech team to qualify for the spring part of European competition for three successive years, but extending our campaign is a great motivation in itself. The players remember the atmosphere of those knockout ties and we all know that only extraordinary clubs are in the draw. We were there twice and I hope Plzen will be there again. I will give my all to achieve that."
CSKA have been a little disappointing this Champions League campaign, with the Russian side unable to give Manchester City a run for their money for second place in the group. A third-place finish will be seen as a must to make up for their lack of competitiveness in the Champions League.
"A tough match awaits. Plzen presented themselves in a very good light and played very well in the first game against us, so we know it will not be easy," CSKA manager Leonid Slutski said. But our aim is to get a result that will take us into the Europa League. It is one of two prestigious European competitions and a priority for us. We are very motivated to get the right result."
Team news: Viktoria Plzen: Vrba has a full squad to choose from.
CSKA Moscow: Seydou Doumbia, Vasili Berezutski, Mario Fernandes and Aleksandrs Cauņa (toe) are all sidelined but Keisuke Honda is available.
Where to Watch Live
The game is scheduled for a 1.15 am IST start on early Wednesday morning with no live coverage in India. You can live stream the match by clicking HERE. Viewers in the U.S. can catch the action via live streaming HERE. To watch the match in the U.K., click HERE. Viewers in North Africa and the Middle East click HERE.
Expected lineups: Viktoria Plzen: Kozacik; Hubnik, Prochazka, Rajtoral, Cisovsky, Horava, Horvath, Kovarik, Tecl, Wagner, Bakos.
CSKA Moscow: Akinfeev; Ignashevich, A Berezutski, Nababkin, Schennikov; Wernbloom, Milanov, Tosic, Honda, Dzagoev; Musa.