Floods in Missouri forced hundreds of residents out of their homes on Tuesday after four days of storms sent rivers to record levels, killing at least 13 people, closing hundreds of roads and halting shipping on the swollen Mississippi river.

A week of chaotic weather continued throughout the United States as a storm system that spawned deadly tornadoes in the Midwest and Southwest pushed north. More than 40 people across the country have died of weather-related causes during the Christmas holidays in the past week.

Missouri has been pounded by downpours since Saturday, and forecasters warned that its major rivers could crest between Wednesday and Saturday at records.

"Flooding on the middle portion of the Mississippi River and its tributaries may reach levels not seen during the winter months since records began during the middle 1800s," Alex Sosnowski, senior meteorologist, wrote on AccuWeather.com.

At the confluence of the Mississippi and Missouri rivers, about 20 miles (32 km) north of St. Louis, residents of the towns West Alton and Arnold were told to evacuate on Tuesday.

"Access to and from town will be lost in a matter of hours," the local Rivers Pointe Fire District said in an alert. Video from local news helicopters showed homes in West Alton with water almost at roof levels.

Arnold residents scrambled to find hotels or move to shelters.

Sarah Quinn, 18, said she and her great-grandparents were moving to a hotel room after police turned off the power at her subdivision. Her sister, grandmother and other relatives decided to brave it out without power because they wanted to stay in their homes and vehicles to look after their pets.

"I've never had this happen before. We've had simple flooding in the back of our subdivision and we've had to sandbag before, but it wasn't this severe," said Quinn, who spok by telephone, from her job in a local restaurant.

The Bourbeuse River crested on Tuesday at an all-time record in Union, Missouri, after flooding about 25 homes, nine businesses and the city's sewer system, Mayor Mike Livengood said.

"It will take major work to get those businesses up and running again," Livengood said. He said no one was injured in the town of about 10,500 people in Franklin County, just southwest of St. Louis.

Missouri Governor Jay Nixon called out the National Guard to direct traffic away from hundreds of closed roads across the state and urged drivers not to drive into flooded areas. Most deaths in flooding occur when cars are swept away.

Three new flood-related deaths were discovered on Tuesday, the governor said, raising the death toll in the state since the storms began over the weekend to 13.

"These citizen soldiers will provide much-needed support to state and local first responders, many of whom have spent the last several days working around the clock responding to record rainfall and flooding," Nixon said in a statement.

Nixon will visit Franklin County on Wednesday to tour of flood-fighting efforts in Pacific, where the Meramec River continues to rise above flood stage. The river is expected to crest on Wednesday evening more than 2 feet above the previous record set in 1982.

Across the Mississippi, in Illinois, some inmates were moved out of the Menard Correctional Center, a maximum security prison on the banks of the river, and sandbags and drinking water were prepared in anticipation of flooding in lower level cell blocks, Illinois officials said in a statement.

The US Coast Guard closed a five-mile (8 km) stretch of the Mississippi River near St. Louis to all vessel traffic due to hazardous conditions.

The National Weather Service forecast the Mississippi River at the Chester, Illinois, river gauge about 60 miles (100 km) south of St. Louis would crest at 49.7 feet (15.1 meters) on Friday - matching the 1993 record.

Local officials and the US Army Corps of Engineers were working to fortify a levee in the area to protect homes and businesses.

On Saturday, the Mississippi is expected to crest at Thebes, Illinois, just south of Cape Girardeau, Missouri, at 47.5 feet (14.5 meters) -- nearly two feet above the record, officials said.

Other rivers are also expected to reach new highs, with the Meramec forecast to crest at Valley Park, Missouri, at a record 42 feet (12.8 meters).

Illinois issued a disaster proclamation for seven counties with flooding or potential flooding after being drenched with seven inches of rain between 23-28 December.

Elsewhere in the US midsection, parts of eastern Oklahoma and Arkansas, were under flood warnings and flood watches on Tuesday. Up to a foot (30 cm) of snow was forecast for Iowa and the Great Lakes region, the National Weather Service said.

The severe weather has stranded tens of thousands of travelers during one of the busiest travel periods of the year. As of 9:30 p.m. EST on Tuesday, more than 1,440 flights had been canceled in the United States and about 8,500 were delayed, according to FlightAware.com.