Rocket-propelled grenades struck a hotel in Yemen's Aden city where Prime Minister Khaled Bahah has been residing, and at least 15 members of the Saudi-led coalition were reportedly killed.
The prime minister escaped unhurt in the attack, as per reports. The Yemeni prime minister is also the vice president of the country.
At least three grenades were fired and one struck the entrance of the AlQasr Hotel early on Tuesday, Al Arabiya reported.
Several people were left "dead and wounded" in the attack, an official told AFP.
UAE news agencies have reported that 15 members of the coalition were killed in the rocket attacks.
Several government officials have been residing at the AlQasr Hotel in Aden since their return from exile from Saudi Arabia.
Locals in Aden reportedly heard several explosions and images posted on Twitter showed thick smoke rising from the building. A short video clip was also shared on Twitter showing a large explosion at the hotel.
— Yemen Post Newspaper (@YemenPostNews) October 6, 2015
— Zaid Benjamin (@zaidbenjamin) October 6, 2015
Yemen's Shia Houthi rebels have been launching attacks to topple the government and seize control since last year.
Saudi Arabia has accused Iran of backing the rebels and led a coalition to carry out airstrikes against the Houthis.
Yemen has also fallen to Isis attacks in recent months, with a bomb blast on Eid al Adha at a mosque killing numerous worshippers.