Come Sunday at Old Trafford, it won't just be the Manchester United fans who will be rooting for their team to pull off a victory against Chelsea, there will be supporters across town wearing the blue of Manchester City, with a few more in red of Liverpool and Arsenal thrown in as well.
Chelsea have made as strong a start as could have been hoped for, with new signings Diego Costa and Cesc Fabregas in stupendous form, and it will now be up to Louis Van Gaal and his shaky-in-the-defence-but-scary-when-they-feel-like-in-offence side to halt the Jose Mourinho-led juggernaut.
Van Gaal knows all about Mourinho, having had him as his assistant in the past, and it will be interesting to see if the master still has the mojo to get one over his former pupil.
"I don't know him as a manager because I am never there," said Van Gaal when asked about Mourinho. "I know him as a person and as my assistant manager.
"We hardly speak to each other, only sometimes on SMS. When we see each other, we feel the warmth between us and our families, which is nice."
While one eye will be on the touchline, to see just how the two managers react on, especially if the match does het heated up a little, as these big games tend to do, what will also be a point of interest will be the players on the field.
Chelsea have been functioning as a smooth, ruthless and ridiculously powerful machine this season, showing little regard for the opposition, with that man Costa scoring goals for fun.
However, there is a major doubt over the Spain international's availability again, even if the latest reports suggest that the summer signing will win his fight for fitness from a hamstring injury and a stomach bug.
Mourinho was coy when asked about Costa's availability for this massive English Premier League clash against Manchester United, who are currently ten points behind their opponents.
"I don't protect players before a Man United game, unless he cannot play," Mourinho said. "If there is a chance of playing, Old Trafford is not the place to protect players, it is the place to put the players who want to play and are ready to play. If Diego is ready to play, he plays.
"I still don't know who is available. Normally two days before the game I know the team, I have no doubts, everything is clear in my brain. Now I need a lot of talk and information to finally make a decision."
Cesar Azpilicueta is suspended and Ramires and John Obi Mikel are also struggling to make the squad, while Manchester United have worries of their own with star striker Radamel Falcao rated as a doubt after picking up a knock in training.
Van Gaal, though, was quick to dispel fears of a recurrence of a knee injury, which kept Falcao out for a long time last season.
"He got a kick in the morning [on Friday] so we have to wait and see if he's fit enough," said Van Gaal. "But it's not a knee problem.
"He had a knee problem but not anymore. We have to build Falcao up, that I have also said in the first press conference when he came to our club.
"It is difficult because we are playing [games] already, that's difficult but we have played him because I like the way he was playing so we play with two strikers. Now I have to choose between two strikers, even three because [James] Wilson can also play, the younger player."
Van Gaal does not have skipper Wayne Rooney to call upon either, with the forward serving the final one of his three-match suspension, while Antonio Valencia and Jonny Evans will also miss out, but the already-inspirational Angel Di Maria is fit after the midfielder came off injured in Manchester United's 2-2 draw with West Brom on Monday night.
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The big EPL match is set for a 4 pm BST (9.30 pm IST, 10 am ET) start with live coverage on Star Sports 2 and Star Sports HD2. The match can also be watched via live streaming online in India on Star Sports.com. Live TV coverage in the UK will be on Sky Sports 1, with the option to live stream the match also available via Sky Sports Online or Sky Go. Viewers can also listen to the action via radio on BBC Radio 5 Live or on the website. Watch the game in the US on NBC Sports, while the action can also be Live Streamed online on NBC Sports Extra.
Australia viewers catch the Manchester United vs Chelsea match via live streaming on Fox Sports On Demand, while viewers in Canada can do the same Watch Sportsnet. Viewers in the Middle East and North Africa can watch the match via Live Streaming online courtesy Bein Sports Connect, while South Africa and Sub Saharan Africa viewers can do so via SuperSport online. Latin America and South America viewers can catch the match on ESPN or ESPN Play.
Confirmed lineups: Manchester United: De Gea; Rafael, Smalling, Rojo, Shaw; Di Maria, Blind, Fellaini, Mata; Van Persie, Januzaj.
Chelsea: Courtois; Ivanovic, Cahill, Terry, Filipe Luis; Matic, Fabregas; Willian, Oscar, Hazard; Drogba.
