Serena Williams US Open 2016
Serena Williams is all smiles after creating a new Grand Slam recordReuters

Andy Murray put out a statement with a demolition job of Grigor Dimitrov, while Serena Williams continued to break records on another day of exciting action at the US Open 2016.

Serena, with her win in the third round, had crossed Martina Navratilova and equalled Roger Federer's mark of all-time victories in Grand Slams at 307. It was only a matter of when she would stand alone on 308, and that when came on Monday courtesy the American's 6-2, 6-4 fourth round win over Yaroslava Shvedova.

"It's a huge number," Serena said after winning her 308th match in a major. "I think it's very significant, actually. I think it's something that just really talks about the length of my career, in particular.

"I've been playing for a really long time, but also, given that consistency up there. That's something that I'm really proud of. I'm just enjoying these moments out here, getting to break records that I didn't even know existed or I didn't even know were possible."

While Murray will not get anywhere near that record of Serena's, the Brit looks on course to challenge for his second US Open title, after a assured fourth round performance against No.22 seed Dimitrov. Coming into this match with doubts lingering over his serve, following a below par showing against Paolo Lorenzi in the third round, Murray showed he is still the man to beat at this Grand Slam with a 6-1, 6-2, 6-1 thumping of the Bulgarian in two hours and one minute.

Joining Murray in the quarterfinals in the men's singles are Stan Wawrinka, Kei Nishikori and Juan Martin Del Potro. Wawrinka overcame a third set dip to beat Illya Marchenko 6-4, 6-1, 6-7 (5-7), 6-3.

Nishikori, who will face Murray in the final eight, was too hot to handle for the big-serving Ivo Karlovic, with the No.6 seed winning 6-3, 6-4, 7-6 (7-4).

The feel-good result of Monday, though, was that of Del Potro's. The 2009 US Open champion, given a wild card in this US Open and ranked only 142 at the moment owing to persistent wrist injuries, entered the quarterfinals after Dominic Thiem retired due to a knee problem. Del Potro was leading 6-3, 3-2 when the No.8 seed decided he cannot continue.

In the women's singles, Serena's sister Venus crashed out, despite taking the first set against Karolina Pliskova. Venus, after winning the first set, looked in complete control of the match, but once Pliskova found her rhythm in her serve, the match turned, with the Czech entering the last eight of a major for the first time in her career after a 4-6, 6-4, 7-6 (7-3) win.

The No.5 seed Simona Halep is also through, thanks to a 6-2, 7-5 victory over the experienced Carla Suarez-Navarro. Halep will next face Serena in the quarterfinals.

The big upset in the women's singles on Monday came when 18-year-old Ana Konjuh topped No.4 seed Agnieszka Radwanska 6-4, 6-4 in the final match of the day at the Arthur Ashe Stadium.

In Indian interest, Sania Mirza and Barbora Strycova entered the quarterfinals of the women's doubles after a 6-4, 7-5 win over Nicole Gibbs and Nao Hibino. The No.7 seeds will now face off against the top seeded pairing of Caroline Garcia and Kristina Mladenovic.

Rohan Bopanna's campaign at the US Open ended on Monday, when the Indian and his Canadian mixed doubles partner Gabriela Dabrowski lost to Anna-Lena Groenefeld and Robert Farah 1-6, 6-2, 10-8.