Manchester City and Tottenham Hotspur take on each other at White Hart Lane as both sides concentrate on finishing the season strongly.
The Citizens' chances of defending the Premier League title are effectively over as Chelsea are just three points away from being crowned the English champions.
So City will now be hoping to do on the next best thing and finish as the runners up ahead of Arsenal and Manchester City.
However, that is easier said than done as the Citizens have not been in the greatest of forms of late, having recorded three wins and three defeats in their last six fixtures.
Although they are currently above Arsenal on goal differences in second place, they will only retain their spot if the Gunners drop points in their remaining Premier League fixtures.
This is because the Gunners still have a game in hand due to their involvement in the FA Cup.
The Citizens, who have thumped the Spurs during the two sides' last three Premier League meeting, scoring 15 goals and conceding 2, are not expected to do the same on Sunday as City have not been playing poorly of late.
And City boss Manual Pellegrini admits that this fixture to be "very tough" for his side.
"I think it is a very tough game because Tottenham have a good team and good players and a good manager," Pellegrini told Eurosport. "They always play in an offensive way so we must work very hard in defence."
He feels that the match will be very interesting due to the two sides having their own reasons to win on their minds.
"They need to qualify for the Europa League and we must try to be as near to the top of the table, so it will be two teams that play well and try to attack most of the time. I hope we play a very good game for the fans and that is important."
Tottenham, on the other hand, will also be looking to get a positive in this fixture as they push for a place in next season's Champions League.
Despite not having the best of campaigns this season, Tottenham have managed to record some memorable wins over the likes of Chelsea and Arsenal.
And now they will be hoping to take advantage of City's recent drop in form and get another positive result on Sunday.
Despite admitting that this fixture against City will be "very tough", Spurs boss Mauricio Pochettino insists that his side will be looking for nothing less than a win on Sunday.
"It's a very tough game, City are one of the best teams in England but this is an opportunity in front of our supporters to play well and try to win the game," Mauricio told the Spurs official website.
"It's true, but in the same way we know this is a very good team with very good players," he added. "We always believe in our possibilities. We need to be strong and to try our best to win."
Tottenham Hotspur: Lloris, Dier, Fazio, Vertonghen, Davies, Bentaleb, Mason, Chadli, Eriksen, Townsend, Kane
Manchester City: Hart, Zabaleta, Demichelis, Mangala, Kolarov, Fernandinho, Lampard, Navas, Milner, Silva, Aguero
Where to Watch Live:
The EPL match is scheduled for 7:45pm BST (12:15pm IST, 2:45am ET), starting with live coverage in India on Star Sports 4 and Star Sports 4 HD in India. The game can also be watched via live streaming online in India on StarSports.com.
Catch the action live in the UK live on Sky Sports 1 and Sky Sports 1 HD, while viewers can also watch the watch online via live streaming on Sky GO. Catch the game live in the US on NBCSN, while the action can also be live streamed online on NBC Sports Extra.
Audience in the Middle East and North Africa can watch the game via live streaming online on Bein Sports Connect, while South Africa and Sub-Saharan Africa viewers can do the same on SuperSport online. Australia viewers can watch the game on Fox Sports 4 and live stream it on Foxtel Play.