Real Madrid take on Almeria at Santiago Bernabéu Stadium as they look to put pressure on La Liga leaders Barcelona.
After sitting at top of La Liga for most of the season, Real Madrid were displaced from the top of the table by Barcelona, following a string of poor results in March.
The Los Blancos have been playing well ever since, but they are still five points behind Barcelona in the La Liga, and the Catalans have been showing no signs of faltering at the top of the table.
And now time seems to be running out along with Real's hopes of securing the La Liga title due to their being only five games left until the end of the season.
Real Madrid need to secure wins in all their remaining La Liga fixtures if they want to keep their hopes of winning the title alive.
"Our objective in La Liga is to win all the remaining games," said the former Real Madrid boss, according to ESPN.
The Italian admits that his side are currently in a do-or-die situation, and they will be approaching this game against Almeria with the same mentality.
"All the games are a matter of life and death now," the former AC Milan coach told Real Madrid's official website.
"We will approach this match with that mentality. This is going to be an important fixture. A tricky and challenging game. We are entering into a stage of the season in which all our encounters will determine the outcome of the future.
"We are going to try to be at our best. The team are in good shape, playing well, and we can play with full intensity for the final stage of the season."
Almeria, on the other hand, will also be looking for nothing less than a win as they are currently dangerously close to the relegation zone and a defeat on Wednesday could hamper their chances for survival.
After failing to record a single win in eight La Liga fixtures from mid-February to early April, Almeria have been a little better of late, recording two wins in their last three league games.
Sergi Barjuan still have some tough fixtures against Sevilla and Valencia remaning, but they will be able to gather a lot of confidence if they manage to get a positive against Real Madrid.
However, that is much easier said than done as Real have been in excellent form of late, recording consecutive wins in their last five league games.
And Almeria boss Barjuan insists that his side need to be much tighter while playing against teams likes Real Madrid.
"We need to be tighter against the big teams so they don't destroy you," Barjuan told reporters at the pre-match conference, according to Football Espana.
Almeria were able to record a comfortable 2-0 win against Eibar in their last fixture, and the former Barcelona left-back insists that his side are working very hard in training to get more positive results in the final stretch of the season.
"Last weekend against Eibar we did things well and improved," he added. "Every day we are spending many hours working together ahead of the challenges we have in front of us, which can be so difficult to achieve."
Real Madrid: Casillas; Arbeloa, Pepe, Varane, Marcelo; Silva, Kroos, Isco; James, Hernandez, Ronaldo
Almeria: Ruben; Dubarbier, Trujillo, Mauro, Ximo; Verza, Thomas, Corona; Espinosa; Hemed, Zongo
Where to watch live
The La Liga match is set to begin at 8pm local time (11:30pm IST, 7pm BST, 2pm ET) with live coverage in India on Star Sports 2 and Star Sports HD 2. Viewers in India can also catch all the action via live streaming online on Starsports.com.
Viewers in the UK can catch all the action on Sky Sports 5 and Sky Sports 5 HD, while the option to live stream is on Sky Go. The game will be shown live in the US and Canada on Bein Sports USA and Bein Sports Canada respectively with the live streaming option on Bein Sports Connect.
Viewers in the Middle East and North Africa can catch the match on Bein Sports Arabia or Bein Sports Connect, while the audience in Australia can enjoy the action live on Fox Sports 4 and Foxtel Play.