Manchester United will have Wayne Rooney available, while Alexis Sanchez took part in full training on Friday in a boost for Arsenal. There are other injury worries for both Jose Mourinho and Arsene Wenger, though, and how well they cope with those absences will have a huge bearing on the result of this big Manchester United vs Arsenal Premier League match at Old Trafford on Saturday.
Rooney missed England's friendly against Spain on Tuesday with a knee problem, but having also come under a storm for unflattering pictures of a night out, there were doubts over the club captain's possible inclusion in this game.
However, Mourinho revealed Rooney is fit and fine and will be a part of the Manchester United squad. Whether he starts the game against Arsenal or not, remains to be seen.
"Over the last two or three days, nothing happened," Mourinho said. "He trained like everybody else, he wants to play like everybody else. He is ready."
Another player available after facing criticism, this time from Mourinho himself, is Luke Shaw, with the left-back missing Manchester United's last Premier League game against Swansea as well as the international week. Mourinho, though, had questioned Shaw's commitment after the defender pulled out of the squad to face Swansea, but the manager has now said he harbours no ill-feelings.
"He is ready to play and I don't have any problem with him," Mourinho added. "I am not saying that he plays or he doesn't play, I am just saying that he is my player, a player with potential, but like every young player he has little problems and things he needs to learn and to improve on."
Chris Smalling is likely to miss the game with a foot injury, although Mourinho refused to confirm if the defender has indeed broken his toe, while the Manchester United manager will also have to do without Eric Bailly.
Marouane Fellaini, a player Mourinho likes to use in the big games, is a doubt, after returning from the Belgium squad early, but the big miss for Mourinho will be Zlatan Ibrahimovic, who is suspended after picking up his fifth yellow card of the season in the win over Swansea.
While Ibrahimovic is not quite Manchester United's talisman yet, Arsenal's at the moment is Alexis Sanchez, and there were major doubts over the forward's fitness after he picked up a hamstring injury while on Chile duty. But having played and scored for his country in a 3-1 win over Uruguay, Sanchez came back on Thursday and was a part of the Arsenal training session on Friday.
Arsene Wenger might still choose to start Sanchez from the bench, but the manager will be tempted to play the 27-year-old from the start, purely because of the energy he gives at the start of the game, which could prove to be crucial in finding that opening goal, so crucial in big-game matches like this.
While Sanchez is set to feature in some capacity, Hector Bellerin and Santi Cazorla won't, with the duo out with ankle and Achilles injuries respectively. Danny Welbeck and Per Mertesacker continue to be long-term absentees.
Confirmed starting XI: Manchester United: De Gea; Valencia, Jones, Rojo, Darmian; Carrick, Herrera; Mata, Pogba, Martial; Rashford.
Arsenal: Cech; Jenkinson, Mustafi, Koscielny, Monreal; Coquelin, Elneny; Walcott, Ozil, Ramsey; Sanchez.