Reiterating his tough stance against Israel, Iranian supreme leader Ayatollah Ali Khamenei has told his hard-line supporters that the country would cease to exist in the next 25 years. He even referred to the United States as a "Great Satan", as he made it clear that Iran would not get into any new negotiations with the country.

"After nuclear negotiations, the Zionist regime said that they will not be worried about Iran in the next 25 years," Ayatollah Khamenei wrote.

"I am telling you, first, you will not be around in 25 years' time, and God willing, there will be no Zionist regime in 25 years. Second, during this period, the spirit of fighting, heroism and jihad will keep you worried every moment," Khamenei said prophetically on Wednesday.

The remarks that were published on Ayatollah's personal website and Twitter handle were accompanied by a photograph, which shows the Iranian leader stepping on an Israeli flag on a sidewalk.

'US is the Great Satan,' some insist on depicting this Great Satan as an angel. We allowed negotiation with US only on nuclear issue for certain reasons, in other areas we did not and will not...
- Ayatollah Khamenei

Ayatollah Khamenei's anti-US statement comes at a time when the moderates in Iran, including Foreign Minister Mohammad Javad Zarif, have been hinting at a possibility of a meeting to discuss a solution for the Syrian war with the western superpower and its allies, NYTimes reported.

"'US is the Great Satan,' some insist on depicting this Great Satan as an angel. We allowed negotiation with US only on nuclear issue for certain reasons, in other areas we did not and will not allow negotiations with US," Khamenei said on Wednesday.

He said that the US officials use negotiations as the "means of infiltration and imposition of their wills". Iran is ready to "negotiate and reach agreement in different levels of state, religion or ethnic groups", but not with "the Great Satan", he said.