Two teams leading their respective divisions clash in a mega-charged Monday Night Football game at the Azteca Stadium in Mexico City, with the Houston Texans and the Oakland Raiders looking to firm their grip on their positions and a possible place in the playoffs.
The Raiders lead the AFC West standings with a 7-2 record, and with the Kansas City Chiefs and the Denver Broncos at 7-3, this is a must-win game for Oakland in order to stay atop the standings.
Houston are much more comfortably placed in the AFC South, with another win in the MNF game taking them to 7-3 and a dominant lead, with their closest rivals in the division being Indianapolis at 5-5.
So, in a way, this game is more important to the Raiders, the designated home team in this first game in Mexico City since 2005, and rightly too considering the support Oakland has received, than to the Texans.
Coming off a bye week, Oakland will be mindful of a quell in momentum, which had been created by a three-game winning run, including an impressive 30-20 win over division rivals Denver Broncos.
"I feel like our team has really been pretty good about acknowledging what went well and what needs to be better and just kind of putting it behind us regardless," Raiders head coach Jack Del Rio said when asked what his team had done during the extra week off.
"That's what we did. That's what we did after a big win. That's what we've done after a tough loss. It's going to be the same, there's a little bit of continuity.
"Our guys understand that. That's how we do it. That's part of the process. It helps you kind of focus on the next task. That's what's most important anyways, what you're doing next, so that's where we are."
The Texans have won two consecutive games and three of their last four, but they will expect one of their stiffest tests of the season when they face off against Oakland in front of the fans in Mexico.
Where to Watch Live
The MNF game in Mexico City is scheduled for an 8.30pm ET (7am IST, 1.30am GMT) start. Live Streaming and TV information is below.
India: TV: Sony ESPN and Sony ESPN HD. Live Streaming: Sonyliv.
USA: TV: ESPN and ESPN Deportes. Live Streaming: Watch ESPN.
Mexico and Latin America: TV: ESPN. Live Streaming: ESPN Play.
UK: TV: Sky Sports 1. Live Streaming: Sky Go.
Canada: TV: TSN1, 3, 4, 5. Live Streaming: TSN TV.
Australia: TV: ESPN. Live Streaming: Foxtel.
International: Live Streaming: NFL Game Pass.