Alex became "Meredith's person" shortly after her best pal left Grey Sloan Memorial Hospital for better opportunities abroad, and it looks like his new closeness to Meredith could come in the way of his relationship with Jo.
Alex and Jo have had their issues in the past, and Meredith could become a potential threat as they move forward.
According to actress Camilla Luddington, who plays surgical resident Jo, there's something "completely missing" in Jo's relationship with Alex Karev.
"I'm not sure Alex does a good job of being there for his friend but also letting his girlfriend know that he's there for her too," Luddington told People.
For instance, in one of the previous episodes, viewers saw Alex being worried when he noticed Penny's presence affecting Meredith, but he wasn't readily available when his girlfriend wanted a shoulder to lean on during her relationship crisis with Stephanie.
"I think that at the dinner party, for example, we saw that he had that intuition that something was wrong with Meredith, but it seems to be completely missing for Jo, which I'm not sure what that says," she continued.
Sadly, that wasn't the only time Alex shut out Jo, and made a decision that they should have taken as a couple. Towards the end of season 11, we saw Alex inviting Meredith to move back into the home he shared with Jo. He also never bothered to consult with Jo when he thought of inviting Arizona to crash at their place.
"At some point, maybe if they are to move forward and be serious and get married and have kids, that should be addressed," feels Luddington.
It remains to be seen how Alex and Jo handle the issues that are bound to crop up in their relationship. As for what happens next Thursday, here's what the official synopsis for "Things We Lost in the Fire" states:
As the rumor mill around the hospital continues to spiral out of control, Grey Sloan Memorial is flooded with injured firefighters from a nearby wildfire. Maggie struggles to keep things with Andrew professional at work. Meanwhile, Jo questions Alex's priorities.
"Grey's Anatomy" is aired Thursdays on ABC.