Angelina Jolie and Brad Pitt have called it quits after 12 years. Jolie's lawyer, in a statement, cited "irreconcilable differences" as the reason and said that the Oscar-winning actress has filed for divorce from her husband Pitt.

According to the court documents, Jolie and Pitt, who are famously called as Brangelina, were separated on September 15.   

Brad Pitt and Angelina Jolie in 2005
U.S. actors Brad Pitt (L) and Angelina Jolie (R), stars of the new action film "Mr. & Mrs. Smith" pose with one of the film's producers, Arnon Milchan of New Regency at the film's premiere in Los Angeles June 7, 2005.Reuters

"This decision was made for the health of the family. She will not be commenting, and asks that the family be given its privacy at this time," Jolie's lawyer Robert Offer said in a statement.

"I am very saddened by this but what matters most now is the well-being of our kids," Pitt told People magazine in a statement. "I kindly ask the press to give them the space they deserve during this challenging time."

Brangelina were one of the most high-profile couples in the entertainment world. Jolie and Pitt started dating in 2005 and got married in August 2014. Their relationship remained steady for over a decade, but soon after marriage reports of trouble in paradise started doing the rounds. And two years after their marriage they have called it quits.

Social media users reacted on Twitter with shock and expressed sadness over the breakup news. #Brangelina hashtag was used around 720 times per minute on Twitter after the news of Pitt and Jolie ending their marriage broke, according to Reuters.

Here is a look back at Brangelina's 12-year romance in photos:

Brad Pitt and Angelina Jolie in 2006
Haitian police escort Angelina Jolie (Bottom C) and Brad Pitt (2nd R) as leave the airport during a short visit to Port-au-Prince, Haiti January 13, 2006.Reuters
Brad Pitt and Angelina Jolie in 2007
Executive producer Brad Pitt and actress Angelina Jolie attend the premiere of 'God Grew Tired of Us' at the Pacific Design Center in Los Angeles January 8, 2007. The documentary tells the odyssey of three young Sudanese men who embark on a journey to America in search of safety.Reuters
Brad Pitt and Angelina Jolie in 2008
Cast member Angelina Jolie and actor Brad Pitt arrive for the screening of the film "The Exchange" by U.S. director Clint Eastwood at the 61st Cannes Film Festival May 20, 2008.Reuters
Brad Pitt and Angelina Jolie in 2009
U.S. actors Brad Pitt and Angelina Jolie arrive with their children at Narita airport, near Tokyo, January 27, 2009.Reuters
Brad Pitt and Angelina Jolie in 2010
Actors Brad Pitt (R) and Angelina Jolie are seen on the set of Jolie's yet untitled directorial debut in Budapest November 8, 2010.Reuters
Brad Pitt and Angelina Jolie in 2011
Cast member Brad Pitt and actress Angelina Jolie arrive on the red carpet for the screening of the film "The Tree of Life", by director Terrence Malick, in competition at the 64th Cannes Film Festival, May 16, 2011.Reuters
Brad Pitt and Angelina Jolie in 2012
Actors Brad Pitt and Angelina Jolie depart at the end of the 18th annual Screen Actors Guild Awards in Los Angeles, California January 29, 2012.Reuters
Brad Pitt and Angelina Jolie in 2013
Angelina Jolie and partner Brad Pitt and son Maddox arrive at the 5th Annual Academy of Motion Picture Arts and Sciences Governors Awards in Hollywood November 16, 2013.Reuters
Brad Pitt and Angelina Jolie in 2014
Actors Brad Pitt and Angelina Jolie arrive for a special Maleficent Costume Display at Kensington Palace in London May 8, 2014Reuters
Brad Pitt and Angelina Jolie in 2015
Director and cast member Angelina Jolie and her husband and co-star Brad Pitt pose at the premiere of "By the Sea" during the opening night of AFI FEST 2015 in Hollywood, California November 5, 2015.Reuters